TitleEvolution of separate predation- and defence-evoked venoms in carnivorous cone snails
Publication TypeJournal Article
Year of Publication2014
AuthorsDutertre S, Jin A-H, Vetter I, Hamilton B, Sunagar K, Lavergne V, Dutertre V, Fry BG, Antunes A, Venter DJ, Alewood PF, Lewis RJ
Date PublishedMar
Type of ArticleArticle
ISBN Number2041-1723
Accession NumberBIOSIS:PREV201400403578
Keywords(toxin), 01500, Evolution, 22501, Toxicology - General and methods, 64026,, Animals,, Animals, Invertebrates, Mollusks, Cephalopoda [61100], Chordates, Humans, Mammals, Primates, Vertebrates, Evolution and Adaptation, Gastropoda [61200], Hominidae [86215], hunting strategy, Invertebrata: comparative, experimental morphology, physiology and, Mollusca, Invertebrata, Animalia, mollusk]/Primates, Mammalia, Vertebrata, Chordata, Animalia, pathology - Mollusca, Toxicology, venom, [cephalopod]/Mollusca, Invertebrata, Animalia, [Conus geographus] [Conus planorbis] [Conus coronatus] [Conus victoriae, [Conus obscurus], [human]
AbstractVenomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the defence-evoked venom of Conus geographus contains high levels of paralytic toxins that potently block neuromuscular receptors, consistent with its lethal effects on humans. In contrast, C. geographus predation-evoked venom contains prey-specific toxins mostly inactive at human targets. Predation-and defence-evoked venoms originate from the distal and proximal regions of the venom duct, respectively, explaining how different stimuli can generate two distinct venoms. A specialized defensive envenomation strategy is widely evolved across worm, mollusk and fish-hunting cone snails. We propose that defensive toxins, originally evolved in ancestral worm-hunting cone snails to protect against cephalopod and fish predation, have been repurposed in predatory venoms to facilitate diversification to fish and mollusk diets.